In 'Love and Other Drugs,' Jake Gyllenhaal and Anne Hathaway play opposites who attract and then undress one another with pretty steamy frequency. It's a stark departure from their previous onscreen coupling, in 'Brokeback Mountain,' in which the pair first gets busy in the backseat of a car, before dwindling into a loveless marriage.
How does Jake and Anne's romantic reunion stack up compared to other leading men and ladies who've taken a second shot (or shot a second take) at love, Hollywood-style? We're not talking about when characters stay together for the sake of the sequel, but when two movie icons double down on their onscreen chemistry in completely new roles. Here's nine more of them, with our take on which films sizzle or fizzle.