Ready to call it a wrap on all the year-end, best-of-2010 wrap-ups? Us too -- especially when 2011's shaping up to bring us a bevy of Next Big Things. Whether they're starring in reboots, remakes or really edgy indie flicks, the following six actors and actresses are poised to push through big-time by this time next year.

Of course, as much as we love laying bets on who will be the big box-office breakthroughs, we also admit that this is fingers-crossed speculation on our part. In fact, considering how Tom Hardy, our 2010 breakout-star pick, came out of nowhere in 'Inception' to take that title, we'll be just as happy to find in 12 months' time that we've been surprised yet again.