Awards
| Year | Award | Category | Movie | Result |
|---|---|---|---|---|
| 2010 | Academy Awards | Best Actress | The Kids Are All Right | Nominated |
| 2010 | British Academy of Film and Television Arts | Best Actress | The Kids Are All Right | Nominated |
| 2010 | Golden Globes | Best Performance by an Actress in a Motion Picture - Musical or Comedy | The Kids Are All Right | Nominated |
| 2010 | Independent Spirit Awards | Best Female Lead | The Kids Are All Right | Nominated |
| 2010 | London Film Critics Association | Best Actress | The Kids Are All Right | Nominated |
| 2010 | National Society of Film Critics | Best Actress - Runner-up | The Kids Are All Right | Nominated |
| 2010 | New York Film Critics Circle | Best Actress | The Kids Are All Right | Won |
| 2010 | Screen Actors Guild | Best Ensemble | The Kids Are All Right | Nominated |
| 2010 | Screen Actors Guild | Best Actress | The Kids Are All Right | Won |
| 2006 | Academy of Television Arts and Sciences | Best Lead Actress in a Miniseries or Movie | Mrs. Harris | Nominated |
| 2006 | Golden Globes | Best Performance by an Actress in a Miniseries or Motion Picture Made for Television | Mrs. Harris | Nominated |
| 2006 | Golden Globes | Best Performance by an Actress in a Motion Picture - Musical or Comedy | Running With Scissors | Nominated |
| 2006 | Satellite Awards | Best Performance by an Actress in a Motion Picture - Musical or Comedy | Running With Scissors | Nominated |
| 2006 | Screen Actors Guild | Best Actress in a TV Movie or Miniseries | Mrs. Harris | Nominated |
| 2004 | Academy Awards | Best Actress | Being Julia | Nominated |
| 2004 | Boston Society of Film Critics | Best Actress - Runner-up | Being Julia | Won |
| 2004 | Broadcast Film Critics Association | Best Actress | Being Julia | Nominated |
| 2004 | Golden Globes | Best Performance by an Actress in a Motion Picture - Musical or Comedy | Being Julia | Won |
| 2004 | National Board of Review | Best Actress | Being Julia | Won |
| 2004 | Screen Actors Guild | Best Actress | Being Julia | Nominated |
| 1999 | Academy Awards | Best Actress | American Beauty (1999) | Nominated |
| 1999 | British Academy of Film and Television Arts | Best Actress | American Beauty (1999) | Won |
| 1999 | Golden Globes | Best Performance by an Actress in a Motion Picture - Drama | American Beauty (1999) | Nominated |
| 1999 | Screen Actors Guild | Best Female Actor in a Leading Role | American Beauty (1999) | Won |
| 1995 | Golden Globes | Best Performance by an Actress in a Motion Picture - Musical or Comedy | The American President | Nominated |
| 1991 | British Academy of Film and Television Arts | Best Supporting Actress | The Grifters (1990) | Nominated |
| 1991 | Golden Globes | Best Performance by an Actress in a Motion Picture - Drama | Bugsy | Nominated |
| 1990 | Academy Awards | Best Supporting Actress | The Grifters (1990) | Nominated |
| 1989 | National Society of Film Critics | Best Supporting Actress | The Grifters (1990) | Won |
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