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Estelle Reiner's biggest Hollywood role might have been as the real-life mother of director Rob Reiner and wife of actor Carl Reiner, but many fans outside the family's household are still familiar with her face. She made a memorable cameo in the infamous restaurant scene in her son's 1989 film When Harry Met Sally, where Meg Ryan fakes a very loud orgasm. Reiner played one of the many stunned patrons of the restaurant, turning to the waiter after Ryan had finished her performance and quipping "I'll have what she's having." The Bronx native also appeared in other films, like The Man with Two Brains and Fatso. She also worked with the organization Another Mother for Peace, and enjoyed a successful career as a jazz singer, which she embarked upon at the age of 65. She passed away in 2008 at the age of 94.

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