Awards
| Year | Award | Category | Movie | Result |
|---|---|---|---|---|
| 2010 | Academy of Television Arts and Sciences | Outstanding Lead Actress in a Miniseries or a Movie | The Special Relationship | Nominated |
| 2010 | Golden Globes | Best Supporting Actress in a Series, Miniseries or Motion Picture Made for Television | The Special Relationship | Nominated |
| 2008 | Independent Spirit Awards | Robert Altman Award | Synecdoche, New York | Won |
| 2003 | Chicago Film Critics Association | Best Actress | American Splendor | Nominated |
| 2003 | Golden Globes | Best Performance by an Actress in a Supporting Role in a Motion Picture | American Splendor | Nominated |
| 2003 | Independent Spirit Awards | Best Supporting Actress | The Secret Lives of Dentists | Nominated |
| 2003 | National Society of Film Critics | Best Actress - Runner-up | The Secret Lives of Dentists | Won |
| 2003 | New York Film Critics Circle | Best Actress | American Splendor | Won |
| 2003 | New York Film Critics Circle | Best Actress | The Secret Lives of Dentists | Won |
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