Awards
| Year | Award | Category | Movie | Result |
|---|---|---|---|---|
| 2008 | Academy of Television Arts and Sciences | Outstanding Lead Actress in a Miniseries or a Movie | John Adams | Won |
| 2008 | Golden Globes | Best Performance by an Actress in a Miniseries or Motion Picture Made for Television | John Adams | Won |
| 2008 | Screen Actors Guild | Best Performance by an Actress in a Miniseries or Motion Picture Made for Television | John Adams | Won |
| 2007 | Academy Awards | Best Actress | The Savages | Nominated |
| 2007 | Chicago Film Critics Association | Best Actress | The Savages | Nominated |
| 2007 | Detroit Film Critics Society | Best Actress | The Savages | Nominated |
| 2007 | Golden Satellite Award | Best Performance by an Actress in a Motion Picture - Drama | The Savages | Nominated |
| 2005 | Golden Globes | Best Performance by an Actress in a Motion Picture - Musical or Comedy | The Squid and the Whale | Nominated |
| 2005 | Independent Spirit Awards | Best Actress | The Squid and the Whale | Nominated |
| 2005 | London Film Critics Association | Best Actress | Kinsey | Nominated |
| 2005 | Toronto Film Critics Association | Best Actress | The Squid and the Whale | Nominated |
| 2004 | Academy Awards | Best Supporting Actress | Kinsey | Nominated |
| 2004 | Broadcast Film Critics Association | Best Supporting Actress | Kinsey | Nominated |
| 2004 | Golden Globes | Best Performance by an Actress in a Supporting Role in a Motion Picture | Kinsey | Nominated |
| 2004 | National Board of Review | Best Supporting Actress | Kinsey | Won |
| 2004 | National Society of Film Critics | Best Supporting Actress (Runner-up) | Kinsey | Won |
| 2004 | Screen Actors Guild | Best Supporting Actress | Kinsey | Nominated |
| 2001 | Toronto Film Critics Association | Best Supporting Actress [Runner-up] | The House Of Mirth | Won |
| 2000 | Academy Awards | Best Actress | You Can Count on Me | Nominated |
| 2000 | Golden Globes | Best Performance by an Actress in a Motion Picture - Drama | You Can Count on Me | Nominated |
| 2000 | Independent Spirit Awards | Best Actress | You Can Count on Me | Nominated |
| 2000 | National Society of Film Critics | Best Actress | You Can Count on Me | Won |
| 2000 | New York Film Critics Circle | Best Actress | You Can Count on Me | Won |
| 2000 | Screen Actors Guild | Best Actress | You Can Count on Me | Nominated |
| 2000 | Toronto Film Critics Association | Best Actress | You Can Count on Me | Won |
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