A versatile, no-nonsense actress, Margaret Colin has moved easily between TV and films throughout her career, from such acclaimed series as Chicago Hope to Hollywood blockbusters and independent features. Born in Brooklyn to a large Irish-Catholic family and raised on Long Island, Colin began acting in elementary school. Along with winning a drama scholarship to Hofstra University, Colin studied the craft at the Stella Adler Conservatory and Juilliard. Leaving school for a career in Manhattan, Colin soon landed on the TV daytime dramas Edge of Night and As the World Turns in the early '80s. Colin made the move to feature films playing one of teen icon Molly Ringwald's teachers in Pretty in Pink (1986) and psycho Ray Liotta's wife in Jonathan Demme's off-kilter romance Something Wild (1986). With substantial roles in the TV movies The Return of Sherlock Holmes (1987) and Warm Hearts, Cold Feet (1987), and the cop series Leg Work (1987) created as a vehicle for her, Colin was poised to become a small-screen star. Leg Work, however, didn't last beyond its first season. Nevertheless, Colin remained quite visible, appearing as Tom Selleck's love interest in the wildly popular feature comedy Three Men and a Baby (1987) and earning kudos for her turn as an intrepid investigator in the James Woods legal drama True Believer (1989). Back on the small screen, Colin starred in the well-received docudrama Goodnight, Sweet Wife: A Murder in Boston (1990). Though she decided to start a family with husband and erstwhile daytime TV colleague Justin Deas, Colin continued to work regularly. After sharing screen time with such stars as Demi Moore, Nicolas Cage, and Samuel L. Jackson in the ill-received feature comedies The Butcher's Wife (1991) and Amos and Andy (1993), and appearing as a regular guest on CBS's lauded hospital drama Chicago Hope, Colin landed roles in two high-profile movies. As the President's press secretary and addled scientist Jeff Goldblum's ex, Colin was a key part of the ensemble battling an apocalyptic alien attack in the flashy summer blockbuster Independence Day (1996). Harking back to her family's history in law enforcement, Colin was then cast as N.Y.C. Irish cop Harrison Ford's wife in the political thriller The Devil's Own (1997). Despite the presence of Ford and co-star Brad Pitt, however, The Devil's Own was a financial disappointment. Colin fared better, at least critically, with her role as the title character's mother in the indie teen comedy The Adventures of Sebastian Cole (1998). Cast as John Goodman's wife in CBS's supernatural spy series Now and Again (1999), Colin then seemed to be on the verge of regular TV series work again, but Now and Again failed to live up to the hype. After a handful of roles in independent and TV films, including coming-of-age drama and Sundance Film Festival entrant Blue Car (2002), Colin returned to glossy Hollywood product with an appearance as one of Diane Lane's friends in the infidelity potboiler Unfaithful (2002).