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Los Angeles native Sasha Alexander honed her interest in acting with roles in school plays, but soon graduated to a professional career with roles on shortlived series like the drama Wasteland and the wild comedy Greg the Bunny, on which she shared an on-screen kiss with comedian Sarah Silverman. In 2003, Alexander took on the role of Agent Caitlin Todd on the series NCIS. She would play the role for many seasons to come, in addition to roles in movies like Yes Man and Love Happens, and other TV shows, like Rizzoli & Isles.

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