In Venice, Italy, a collection of strangers at a hotel vary from strange to corrupt to disturbed. A film crew from the U.K. is in the process of filming a take on the play "The Duchess of Malfi" by John Webster, while a documentarian records their work behind the scenes. A tour guide (Julian Sands) is hiding something. A call girl establishes herself as a hotel presence, and maids practice strange acts and behaviors. Meanwhile, an assassin (Andrea Di Stefano) frequents the hotel after jobs.
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