Joey Winner (Rob Stefaniuk) is a down and out musician, whose band has been playing to empty clubs for over a decade. When his manager (Dave
Foley) advises Joey to fire him, his girlfriend (Nicole deBoer) dumps him, and a mysterious bartender (Alice Cooper) suggests he should kill himself, hes about ready to call it a night. Everything changes however when bass player Jennifer (Jessica Pare) goes to an afterhours party with rock and roll vampire (Dimitri Coats). When Jennifer returns shes different. She has a charged, sexual, death energy that is perfect for rock. People start turning up to the gigs and seem hypnotized by the new and improved line up. As the band tours down this highway to hell, the body count rises with the ticket sales. The band assumes Jennifer keeps getting sick in the sun and disappears at night because shes on drugs. Once they get past the American border guard (Alex Lifeson) they play shows with the likes of Beef Bellows (Moby), record with an artist in exile named Victor (Iggy Pop), and wind up on The Rockin Roger Morning Show (Henry Rollins). But The Winners are not at the top yet and if Eddie VanHelsig (Malcolm McDowell) has anything to say about it they never will be. When the mysterious bartender returns with an offer for Joey, we realize why so many bands nowadays suck.