"Houseguests and fish both start to stink after three days." -- Italian Proverb.
The ushers and attendants, the family dependents, all that jazz: Carl Peterson (Matt Dillon) and Molly Thompson (Kate Hudson) are getting married. In the rush and crush of a Hawaii wedding, Molly's looking forward to the post-ceremony calm: as she says to a harried Carl, "Remember, when this is all over, it's just you and me." Adding complications is the fact that Carl's lifelong friend Dupree (Owen Wilson) is the Best Man. The position's actually a little ironic, because Dupree doesn't live up to the title. It's not that Dupree is a bad man; it's just that he's not much of a man at all. A free-spirit who lives by whim, Dupree's got a devil-may-care life that people admire ... and, soon after Molly and Carl's wedding, no home. Carl and Molly take pity on Dupree and let him crash with them; after all, how bad can it be?
After Dupree upgrades the house's cable to include HBO, Carl explains Dupree's cohabitation barriers: "He's never really been domesticated; he's like the ape man of Borneo. ..."
Directed by Anthony and Joe Russo (veterans of TV's Arrested Development), You, Me and Dupree is one of those mid-range comedies that charms you more than it knocks you flat. I can't exactly call You, Me and Dupree 'realistic' but it does have a nice, slow-pitch feel; it wants to cajole you into laughter, not beat you silly, and some of the best jokes are slow-burn delayed-fuse numbers that take a few seconds to creep onto your radar, or lie hidden in the background of the scene.