There is a very short list of filmmakers who are so perfectly in tune with my sensibilities, so completely on my wavelength, that each of their projects threatens to collapse my critical faculties and reduce me to a drooling, adoring mess. One such person is little-known Canadian director Vincenzo Natali, whose enigmatic sci-fi mind-blowers Cube and Cypher were about as far up my alley as you could go before it starts to hurt. (I haven't seen Nothing yet, but I will soon.) So I've been hungrily devouring every morsel of information about his upcoming Splice, which is about a pair of scientists (Adrien Brody and Sarah Polley) who discover a way to create new kinds of creatures in the lab by splicing DNA, and then go and introduce human genes into the experiment. My squeamishness about genetic horrors (no joke: I consider Cronenberg's The Fly to be the scariest movie I've ever seen) and my affinity for Natali's approach makes me think this one could really do a number on me.