Why We Can't Wait to See It: Well, it's Indy. That alone is pretty much all you have to say, isn't it? Harrison Ford is back as Dr. Jones, and while some of the folks around for the ride are new (Cate Blanchett, Shia LeBouf and others), the return of Karen Allen as Marion Ravenwood is reason enough for old-school fans to be excited.
Why It Might Do Well: Again, it's Indy -- and a long-anticipated return to the big screen for one of the most beloved movie franchises of modern times. Plus, the only big opener the week before is Prince Caspian -- which, while anticipated, probably won't pull people from the ticket lines opening week.
Why It Might Not Do Well: The question's less if it will do well than if it will be good; interviews have suggested that George Lucas has taken a heavy hand in the writing this time around -- which, frankly, hasn't been a good sign in recent years. Plus there's that disturbing gimmick in the trailer with Indy saying "I thought that was closer ..."; back in the day, Spielberg, Lucas and Ford would have let that go unsaid. ...
Fun Fact: Crystal Skull takes place 19 years after the events of Indiana Jones and the Last Crusade -- the same amount of time it's been since we've seen Indy on-screen.