There's a script to be written, hopefully by someone with talent, in which a character from the real world gets dropped into a romantic comedy. Sort of like Enchanted in reverse, or the middle part of The Last Action Hero -- a reg'lar Joe or Josephine suddenly finds themselves having to survive in the Rom-Com Universe, forced to adapt their normal-human skills and behavior to an alternate reality where almost nothing is like they know it.
Take The Proposal, for example. Ryan Reynolds' executive-assistant character makes a coffee run for his boss -- but there's no coffee in the cups! Seriously, you can tell from the way he's juggling them in one hand that, as in most movies and TV shows, they're completely empty. Unless, of course, normal physics don't apply in Rom-Com World, which is a distinct possibility. Naturally, when he gets the coffee all the way back to the office, the first thing that happens is that he slams into a co-worker, and coffee cascades from the now-full cups all over his shirt.
See, this is one way that it would be hard to live in a romantic comedy. For starters, when I buy coffee, the cup's almost always full of coffee. I like that. And if I was constantly running into people and spilling my magical drink all over myself, I'd need to keep multiple changes of clothes in my car and at my office. I imagine that people in rom-coms must have overnight bags stashed all over the place, given how often they spill stuff, fall down, and have messy things flung at them. It would be hard on the wardrobe.