In 'The Book of Eli', after the war and 'The Big Flash', Eli (Denzel Washington) has been on a journey for 30 years, walking west across the United States. In this post-apocalyptic wasteland, Eli must deal with bands of marauders and thieves who rob and kill just for the fun of it.

Besides being a powerful killer (who ironically believes in peace), Eli is guided by a divine hand to a sacred book. He becomes the protector of the book, and his mission is to take it to its final destination. Eli guards the book with his life, because he knows that the book is the only hope that humanity has for its future.