To say David Lynch is a fascinating man is like saying saying the people on MTV's Jersey Shore are insipid. The words are starting descriptors but their subjects go far beyond such simple terms. But I'll settle for fascinating, as I'm not quite sure I could ever summon a single world to encapsulate the director of Eraserhead, Blue Velvet, Mulholland Dr. and so many others. In case his films don't make it clear, Lynch is a hard intellect to pin down, although the below video should help give some insights into the artist's creative process.
Don't be startled off by its nearly two-hour long run time. Lynch's solo portion starts around the seven-minute mark and runs for about half an hour before quantum physicist John Hagelin takes the podium. While Lynch has the stage to himself, though, he fields all manner of questions concerning Consciousness, Creativity and the Brain (the name of the UC Berkley presentation from which this video was taken). So if you've ever wondered why Lynch is a devotee of Transcendental Meditation and how it effects his artistic process, you'll get plenty of answers here.
If you're interested in more pragmatic questions, such as what inspired some Lynch's earlier films (his response to The Grandmother is particularly interesting) or what is the role of coincidence in his process (the origin of Bob in Twin Peaks is his favorite "happy accident"), he fields just as many questions on the film front as he does the existential side of things. Plus, I just find it hilarious that someone in the audience actually said to David Lynch, "I'm a little confused. I don't know what consciousness really is..."