The Movie:'The Fly' (1958)
The Scene: "As God is my witness, I saw the thing. It's unbelievable, " utters Inspector Charas (Herbert Marshall), shell-shocked from witnessing the ashen, hairless, toothless face of Andre Delambre on the body of a tiny fly, pleading for help while trapped in a spider's web. It's the second big reveal in the 1958 sci-fi shocker, the first being the other half of Delambre's experiment -- a human form with the hideous head of a fly. Earlier in the film, Delambre's teleportation experiments went horribly awry, splicing his body together with that of a fly, creating two new beings that are neither man or insect.
Delambre's tinny cry of "Help me! Help me!" is one of horror's most recognizable bits of dialogue (especially when imitated correctly, in a high-pitched whine). It's a testament to director Kurt Neumann that this incredibly chilling moment still maintains its power to creep us out, even after half a century's worth of jokey references and David Cronenberg's memorable gross-out remake.