In 'Love and Other Drugs,'Jake Gyllenhaal and Anne Hathaway play opposites who attract and then undress one another with pretty steamy frequency. It's a stark departure from their previous onscreen coupling, in 'Brokeback Mountain,' in which the pair first gets busy in the backseat of a car, before dwindling into a loveless marriage.

How does Jake and Anne's romantic reunion stack up compared to other leading men and ladies who've taken a second shot (or shot a second take) at love, Hollywood-style? We're not talking about when characters stay together for the sake of the sequel, but when two movie icons double down on their onscreen chemistry in completely new roles. Here's nine more of them, with our take on which films sizzle or fizzle.
Speed Movie Poster
Based on 17 critics

Los Angeles police officer Jack (Keanu Reeves) angers retired bomb squad member Howard Payne (Dennis... Read More

Before Sunrise Movie Poster
Before Sunrise
Based on 18 critics

On his way to Vienna, American Jesse (Ethan Hawke) meets Celine (Julie Delpy), a student returning to... Read More

Ransom Movie Poster
Based on 21 critics

Through a life of hard work, airline owner Tom Mullen (Mel Gibson) has amassed a great deal of wealth.... Read More

Pretty Woman Movie Poster
Pretty Woman
Based on 18 critics

In this modern update on Cinderella, a prostitute and a wealthy businessman fall hard for one another,... Read More

Titanic Movie Poster
Based on 35 critics

James Cameron's "Titanic" is an epic, action-packed romance set against the ill-fated maiden voyage of... Read More

The Wedding Singer Movie Poster
The Wedding Singer
Based on 21 critics

Set in 1985, Adam Sandler plays a nice guy with a broken heart who's stuck in one of the most romantic... Read More

Runaway Bride Movie Poster
Runaway Bride
Based on 33 critics

Having already left three grooms at the altar, Maggie Carpenter (Julia Roberts) is branded "the runaway... Read More

Lethal Weapon 3 Movie Poster
Lethal Weapon 3
Based on 18 critics

Veteran police detective Roger Murtaugh (Danny Glover) is only days away from retiring when he and his... Read More

How to Lose a Guy in 10 Days Movie Poster
How to Lose a Guy in 10 Days
Based on 31 critics

An advice columnist, Andie Anderson (Kate Hudson), tries pushing the boundaries of what she can write... Read More

50 First Dates Movie Poster
50 First Dates
Based on 38 critics

Playboy vet Henry sets his heart on romancing Lucy, but she has short-term memory loss; she can't remember... Read More

Before Sunset Movie Poster
Before Sunset
Based on 39 critics

A sequel to "Before Sunrise," this film starts nine years later as Jesse (Ethan Hawke) travels across... Read More

The Lake House Movie Poster
The Lake House
Based on 34 critics

A lonely doctor (Sandra Bullock), who once lived in a beautiful lakeside home, falls in love via letters... Read More

Fool's Gold Movie Poster
Fool's Gold
Based on 29 critics

Treasure hunter Ben "Finn" Finnegan (Matthew McConaughey) has sunk his marriage to Tess (Kate Hudson)... Read More

Revolutionary Road Movie Poster
Revolutionary Road
Based on 38 critics

Frank (Leonardo DiCaprio) and April Wheeler (Kate Winslet) always see themselves as far-removed from... Read More

Joe Versus the Volcano Movie Poster
Joe Versus the Volcano
Based on 18 critics

Joe Banks (Tom Hanks) is dying, apparently. This is good news, since his life was not much worth living... Read More

Without Love Movie Poster
Without Love
In Theaters on 1945

Jamie Rowan (Katharine Hepburn) is a widow who decides to do her patriotic duty by marrying military... Read More

Woman of the Year Movie Poster
Woman of the Year
In Theaters on 1942

Tess Harding (Katharine Hepburn) is a progressively-minded political journalist. Sam Craig (Spencer Tracy)... Read More

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