In 'Love and Other Drugs,'Jake Gyllenhaal and Anne Hathaway play opposites who attract and then undress one another with pretty steamy frequency. It's a stark departure from their previous onscreen coupling, in 'Brokeback Mountain,' in which the pair first gets busy in the backseat of a car, before dwindling into a loveless marriage.

How does Jake and Anne's romantic reunion stack up compared to other leading men and ladies who've taken a second shot (or shot a second take) at love, Hollywood-style? We're not talking about when characters stay together for the sake of the sequel, but when two movie icons double down on their onscreen chemistry in completely new roles. Here's nine more of them, with our take on which films sizzle or fizzle.
Based on 17 critics

A SWAT team ace (Keanu Reeves) must save a bus from a madman's (Dennis Hopper) bomb. Read More

December 3, 2016
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Without Love
Not Yet Rated1945
In Theaters on January 1st, 1945

Inventor (Spencer Tracy) and widow (Katharine Hepburn) try platonic marriage in wartime D.C. Read More

Woman of the Year
Not Yet Rated1942
In Theaters on January 14th, 1942

Sportswriter (Spencer Tracy) weds columnist (Katharine Hepburn) whose career comes first. Read More

Before Sunrise
Based on 18 critics

An American (Ethan Hawke) finds love with a Frenchwoman (Julie Delpy) in Vienna. Read More

How to Lose a Guy in 10 Days
Based on 31 critics

A columnist (Kate Hudson) tries to make a man (Matthew McConaughey) dump her. Read More

50 First Dates
Based on 38 critics

A man (Adam Sandler) falls for a woman (Drew Barrymore) who has short-term memory loss. Read More

Before Sunset
Based on 39 critics

Two people (Ethan Hawke, Julie Delpy) reunite in Paris after nine years. Read More

The Lake House
Based on 34 critics

A doctor (Sandra Bullock) and a frustrated architect (Keanu Reeves) fall in love across time. Read More

Fool's Gold
Based on 29 critics

A treasure-hunting pair (Matthew McConaughey, Kate Hudson) embarks on a last quest for booty. Read More

Revolutionary Road
Based on 38 critics

Two suburbanites in 1950s Connecticut become stuck in an increasingly stifling life. Read More

Based on 21 critics

A tycoon (Mel Gibson) threatens his son's kidnappers on television. Read More

Pretty Woman
Based on 17 critics

A corporate raider (Richard Gere) hires a hooker (Julia Roberts) to act as a business escort. Read More

Joe Versus the Volcano
In Theaters on March 9th, 1990

Dying man (Tom Hanks) meets three women (Meg Ryan) on way to Polynesian finale. Read More

Based on 34 critics

A woman (Kate Winslet) falls for an artist (Leonardo DiCaprio) aboard the ill-fated ship. Read More

The Wedding Singer
Based on 21 critics

An entertainer (Adam Sandler) and a waitress (Drew Barrymore) work at weddings. Read More

Runaway Bride
Based on 33 critics

A reporter (Richard Gere) profiles a bride (Julia Roberts) who stood up three grooms. Read More

Lethal Weapon 3
Based on 18 critics

Detectives (Mel Gibson, Danny Glover) and a wild woman crush a guns-to-gangs deal. Read More

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