When you're depressed, cheerful people are basically the most annoying people that ever existed in history.

The Skeleton Twins - Clip No. 1

That's how Maggie (Kristen Wiig) views husband Lance (Luke Wilson) in this exclusive clip from the acclaimed indie drama "The Skeleton Twins." In the film, Wiig and Bill Hader play estranged twins brought together again by their individual depressions.

As Maggie forlornly eats her breakfast, Lance moves through the kitchen like an upbeat tornado. For her, his effervescence is like nails on a chalkboard.

"The Skeleton Twins" opens in theaters September 12.

The Skeleton Twins Movie Poster
The Skeleton Twins
Based on 33 critics

Following many years of estrangement, twins Milo (Bill Hader) and Maggie (Kristen Wiig) have an unexpected... Read More