"The Irishman" is Scorsese's first movie with Netflix and represents one of his most technologically ambitious projects yet.
Based on Charles Brandt's nonfiction book "I Heard You Paint Houses," the film tells the story of Frank Sheeran, who admitted to killing 25 men for the mob, including his friend, the Teamsters boss Jimmy Hoffa.
De Niro plays Sheeran, Pacino is Hoffa, and Pesci portrays Pennsylvania mob boss Russell Bufalino (who allegedly ordered the hit).
The most eyebrow-raising aspect of the film is that it uses advanced CGI to de-age De Niro and Pacino, as they portray their characters over several decades.
"The Irishman" will have open the New York Film Festival in September.
Then, much like it did with last year's acclaimed "Roma," Netflix will release the awards contender in select theaters before debuting it on its streaming service.