4. 'Dollhouse' (2009 – 2010)
It's unclear what, exactly, Whedon could have done to make "Dollhouse" a success. He stocked the creative side with some of his most notable collaborators -- including Tim Minear, Jane Espenson and Steve S. DeKnight -- and filled the cast with notable performers including (but not limited to) Eliza Dushku, Harry Lennix, Fran Kranz, and Olivia Williams. Even the series' premise -- about "Actives" working for a mysterious company that can rewire their personalities for each mission -- was a high concept dream.
But, sadly, the show proved too weird -- too sexy, too confrontational, too provocative -- and it was quietly shuttered after only 26 episodes. Still, it's arguably Whedon's strangest and more challenging show and, would it have aired on Netflix, would have probably enjoyed a long life.