Age is nothing but a number — until that number gets too big to ignore.

Netflix released the first trailer for "The Kominsky Method," a comedy created by Chuck Lorre (of "The Big Bang Theory) and starring Michael Douglas and Alan Arkin as elderly best friends in Los Angeles.

"You know I wake up every morning, my first thought is, I wonder what part of me is not working today,” sighs Norman Newlander (Arkin).

Sandy Kominsky (Douglas) sadly replies, “Yeah, we are passengers on boats slowly sinking."

Norman and Sandy are trying to gracefully tackle life’s inevitable curveballs as they navigate their later years in a a city that values youth and beauty.

The comedy also stars Nancy Travis and Sarah Baker, and boasts a strong lineup of guest stars including  Lisa Edelstein, Emily Osment, Graham Rogers, Danny Devito, Ann-Margret, Jay Leno, Patti LaBelle, and Ashleigh LaThorpe.

"The Kominsky Method" begins streaming November 16 on Netflix.