Mike Tyson vs. Buster Douglas (1990)

Mike Tyson vs. Buster Douglas, billed as Tyson is Back!, was a professional boxing match that occurred at the Tokyo Dome on February 11, 1990. The then-undefeated, undisputed heavyweight champion Tyson lost by knockout to the 42:1 underdog Douglas. The fight is widely regarded as the biggest upset in boxing history.