What happens when you reach the final frontier — and have to come home again?

In the first trailer for "Lucy in the Sky," Natalie Portman grapples with that conundrum. She plays astronaut Lucy Cola, who has a truly out-of-this-world experience on a space mission. When she returns home, Lucy has a difficult time readjusting to normal life with her husband (Dan Stevens).

She begins having an affair with another astronaut (Jon Hamm), but begins to lose her grip on reality when he takes up with another woman.

“Just feel a little off,” she says. “You go up there, you see the whole universe, and everything here looks so small.”

The movie (previously titled "Pale Blue Dot") is the feature film directorial debut for Noah Hawley, the creator of "Fargo" and "Legion." He definitely brings his mind-bending touch to this story, which is loosely based on real-life astronaut Lisa Nowak, who was charged in 2007 with the attempted kidnapping of her paramour's new romantic interest.

"Lucy in the Sky" does not yet have a release date.