The stars, who last worked together in 2011's "Just Go With It," are reuniting for "Murder Mystery," a comedy that will stream on Netflix. Sandler renewed his four-picture deal with the streaming service last year.
The movie centers on a New York City cop who takes his wife on a long-promised European vacation. On the flight, they snag an invite to an intimate family gathering on the yacht of elderly billionaire Malcolm Quince. Then, Quince is murdered and the couple becomes the prime suspects.
The project marks Sandler's sixth under the terms of his deals with Netflix. He most recently starred in Noah Baumbach's The Meyerowitz Stories and can next be seen in "The Week Of" opposite Chris Rock on April 27.
Aniston last starred in 2017's Iraq War drama "The Yellow Birds" and next appears in the pageant movie "Dumplin.'" She's also set to star opposite Reese Witherspoon in an untitled drama about morning show anchors that will stream on Apple.