In the first trailer for "Holmes & Watson," comedy duo Will Ferrell and John C. Reilly are just as bumbling and inappropriate as you'd expect as the legendary Sherlock Holmes and his not-so-bright sidekick.

In this comedy (from "Get Hard" director Etan Cohen), they must save Queen Victoria from a death threat -- while trying not to  accidentally kill her themselves. Or get stung to death by killer bees.

The best bit of casting: Ralph Fiennes is Holmes's archnemesis Moriarty and Hugh Laurie is Sherlock's brilliant brother, Mycroft.

The movie opens December 21.