Who wouldn't want a friend who always says what's on their mind, flirts with everyone in sight, and drinks cocktails before noon like it's no biggie? Karen Walker is that friend and assistant, and she brought her signature boozy sass into "Will and Grace," helping the show become one of the most memorable sitcoms in recent history.

Megan Mullally is a national treasure, and that's why we're celebrating her and one of of her most iconic characters by looking back at some of Karen's best moments. Raise a glass and toast to Karen (or Anastasia Beaverhausen, depending on who you're talking to) and relive the hazy, hilarious memories.