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Ten years ago, "The Hangover" landed in theaters and proved that R-rated comedies can also be huge summer blockbusters. It spawned a franchise and made huge names out of stars like Ed Helms and Zach Galifianakis. To celebrate this big milestone, here are 11 fun facts about the making of "The Hangover."

1. The plot of "The Hangover" is inspired by a similar ordeal suffered by a Hollywood producer named Tripp Vinson. Vinson once went MIA from his own Las Vegas bachelor party and awoke in an unfamiliar strip club with a hefty bill.

2. The screenplay was included on the 2007 Blacklist, a roundup of the most acclaimed scripts not yet made into films.

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3. Ed Helms didn't need any special makeup work done to create his missing tooth. Helms never developed an adult incisor tooth in that spot, so he simply had his dental implant removed during filming.

4.Lindsay Lohan was originally offered the part of Jade. Lohan has since admitted she regrets turning down the role.

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5.Jack Black, Jake Gyllenhaal and Jonah Hill were all considered for the role of Alan Garner, though Alan's portrayal in the script was significantly altered before Zach Galifianakis was eventually chosen.

6. Galifianakis improvised one of Alan's most memorable lines, "I didn't know they gave out rings at the Holocaust." Galifianakis changed the original joke because he wanted to convey Alan's utter ignorance about the wider world.

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7.Ken Jeong has said that he had to get permission from his wife before appearing nude in "The Hangover." Jeong had underwear digitally added to his body for the trailer.

8. Mike Tyson initially turned down an offer to appear in the film, but he changed his mind after learning that Todd Phillips previously directed 2003's "Old School."

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9. Phillips waived his salary in favor of partial ownership of the movie, a decision which paid off handsomely after its release. Phillips compares it to George Lucas' handling of the original "Star Wars."

10. "The Hangover" became the highest-grossing R-rated comedy ever released, beating a record long held by "Beverly Hills Cop."

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11. In 2018, Hasbro released a "The Hangover"-inspired variant of Clue called "Clue: Lost in Las Vegas." which tasks players with finding a missing friend rather than uncovering a murderer.