'Silence of the Lambs' (1991)
This 1991 crime thriller is best known for making Anthony Hopkins' Hannibal Lecter into an iconic Hollywood villain. But while the film itself isn't based on any particular crime, both Lecter and Ted Levine's character Buffalo Bill are inspired by several real-life serial killers. For example, Buffalo Bill shared Ed Gein's compulsion to fashion skin-suits out of his victims and Ted Bundy's habit of luring victims into his vehicle. As for Lecter, it's believed that a Mexican doctor named Alfredo Ballí Treviño was writer Thomas Harris' primary source of inspiration.